4 | Today in Science: Next-generation Sequencing
- Virginia&Frances MD&MS
- Mar 4, 2020
- 1 min read
Updated: Oct 21, 2020
We couldn't wait to cover this amazing technology for biological and medical research, next-generation sequencing or NGS. The history of DNA sequencing took off with Dr. Sanger and end termination. And now, we are able to sequencing entire genomes in a couple of days! For the last ten years, we have really seen an explosion in NGS technology and applications. As promised, our cover photo is an image from the Illumina MiSeq.
Our discussion started with some historical context, but we also got to talk about a range of NGS applications, from ancient DNA to personalized medicine. Also, we brought up some ethical considerations to think about as NGS applications become more accessible. We hope you enjoy the episode.
Sources:
Frances -
The sequence of sequencers: The history of sequencing DNA.
Common applications of next-generation sequencing technologies in genomic research
Coming of age: ten years of next-generation sequencing technologies
The Human Microbiome Project
Next Generation Sequencing of Ancient DNA: Requirements, Strategies and Perspectives
Virginia -
Prenatal cell-free DNA screening
What is noninvasive prenatal testing (NIPT) and what disorders can it screen for?
Cell‐free DNA screening and sex chromosome aneuploidies
Is the quadruple screen better than cellfree DNA testing for prenatal diagnosis of chromosomal disorders?
Personalized medicine: part 1: evolution and development into theranostics.
Ethical, legal and social implications of incorporating personalized medicine into healthcare.
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